Emergence of Lineage E.4 and Structural Plasticity of A28L Protein in Mpox Virus: Characterization of LCR7 Length Polymorphisms Across Lineages - Shenzhen City, Guangdong Province, China, 2023-2025.

Authors

Bo Peng, Ziquan Lyu, Wenxiao Gong, Xiaomin Zhang, Shiting Chen, Wenjuan Ma, Xiaolu Shi, Jia Wan, Jing Qu, Xiaoping Dong

Published in

China CDC weekly. Volume 8. Issue 27. Pages 847-851. Jul 03, 2026.

Abstract

The A28L protein is involved in mpox virus (MPXV) attachment and fusion, is a major target of neutralizing antibodies, and contains regions prone to genetic variation.
Analysis of 6,834 global and 260 Shenzhen MPXV genomes identified lineage-specific length polymorphisms in the A28L low-complexity region (LCR7). Emerging E.4 viruses exhibited complex deletion patterns and a characteristic OPG153_E293Q substitution, indicating ongoing structural diversification.
Structural variation in A28L provides additional insight into MPXV evolution beyond conventional single-nucleotide analyses. Continued surveillance of these genomic features may improve monitoring of viral transmission and the emergence of new variants.

PMID:
42434701
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

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