Dupuytren's disease: a state-of-the-art review.

Authors

Anna Rooth, Viktorija Kaminskaite, Dominic Furniss

Published in

The Journal of hand surgery, European volume. Pages 17531934261463402. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

Dupuytren's disease (DD) is a common chronic hand condition that affects patients worldwide. Presenting with palpable fibrotic nodules, the disease leads to progressive and irreversible flexion of digits, affecting patients' hand function, impairing daily activities and potentially reducing the quality of life. Management techniques are primarily corrective and do not address the biological mechanisms underlying disease pathogenesis and progression. While non-surgical interventions are used to manage early stage DD, advanced disease requires surgical correction. This review provides an overview of the epidemiology and risk factors associated with DD and the latest research on the mechanisms underlying its progression. It summarizes the main non-surgical and surgical corrective options currently available and discusses the future of early stage DD treatment.

PMID:
42433043
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

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