Authors
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L M Solano, Henk Van Loveren, Laurence Vernis, Valentina Tokić, Daniele Cavanna, Yi Liu
Published in
EFSA journal. European Food Safety Authority. Volume 24. Issue 7. Pages e10215. Epub Jul 10, 2026.
Abstract
The food enzyme endo-1,3(4)-β-glucanase (3-(1,3; 1,4)-β-D-glucan 3(4)-glucanohydrolase; EC 3.2.1.6) is produced with the non-genetically modified Rasamsonia composticola strain 427-FS by Kerry Ingredients & Flavours Ltd. The safety of this food enzyme was evaluated previously, and it did not give rise to safety concerns when used in six food manufacturing processes. Subsequently, the applicant has requested to extend its use to include two additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of eight food manufacturing processes. As the food enzyme-Total Organic Solids (TOS) are removed in two processes, the dietary exposure to the food enzyme-TOS was estimated for the remaining six food manufacturing processes. It was calculated to be up to 1.368 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (866 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 633. Based on the revised exposure estimation, the newly derived margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.
PMID:
42434714
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.
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