Authors
Casey Hatfield, Katherine Sage, Gregory Boys, Adam Bruggeman, Om Neeley
Published in
Journal of spine surgery (Hong Kong). Volume 12. Issue 6. Pages 97. Jun 30, 2026. Epub Jun 26, 2026.
Abstract
Spinal fusion surgeries are a common procedure for cervical trauma, degenerative spondylosis, and radiculopathy and/or myelopathy. Though this surgical approach has excellent patient clinical outcomes, there is a paucity of rigorous data quantifying fusion rates at early time points. This retrospective safety and feasibility study evaluates a biphasic calcium phosphate bone graft with submicron surface topography (BCP<µm putty) with or without autograft in anterior cervical discectomy and fusion (ACDF) procedures.
An independent neuroradiologist blinded to the clinical status evaluated computed tomography (CT) images obtained at 6 months and graded each treated level based on the extent of bridging trabecular bone. Twenty subjects were enrolled in the study. A total of 43 spinal levels were treated with an average of 2.15 levels per subject (C3-C4 to C6-C7).
The primary endpoint of CT-based fusion was 97.7% (42/43 levels) based on the presence of bridging bone between the endplates at 6 months. This cohort included 35% of patients treated with BCP<µm putty with ICBG and 65% of patients fused with BCP<µm putty standalone. The observed fusion rates were accompanied by an improvement in pain scores. No graft-related adverse events (AEs) were reported. Limitations of this study include a small sample size and a heterogeneous surgical population.
The high fusion rate observed at 6 months postoperative and favorable safety profile support the performance of BCP<µm putty for use with or without autograft in cervical interbody fusion procedures.
PMID:
42434582
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.
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