Authors
Pranav Dhingra, Aman Kumar, Pooja Mongia Raj, Preeti Patel, Kantrol Kumar Sahu, Balak Das Kurmi
Published in
Inflammopharmacology. Jun 09, 2026. Epub Jun 09, 2026.
Abstract
Oral diseases and neurodegenerative diseases represent two overlapping global health challenges, driven by shared risk factors and the rapid ageing of the population. Emerging evidence suggests that the oral-brain axis functions as a critical mechanistic link between these conditions. Chronic oral dysbiosis, particularly periodontitis, can induce systemic inflammation, disrupt the blood-brain barrier, and promote neuroinflammation, a hallmark of neurodegenerative diseases. Saliva, a non-invasive and easily accessible biofluid, provides valuable insights into both oral and systemic health. This review presents current evidence on the role of salivary protein macromolecules as diagnostic and therapeutic tools within the framework of the oral-brain axis. Key biomarkers, including α-synuclein in Parkinson's disease and amyloid-β and tau proteins in Alzheimer's disease, are highlighted for their diagnostic potential. Furthermore, emerging therapeutic strategies are discussed, including oral health interventions, targeted pharmacological approaches, and the use of salivary proteins and exosomes in regenerative medicine and drug delivery. Advances in analytical technologies, such as mass spectrometry and bioinformatics, are also examined, along with the challenges associated with standardization and clinical validation. Overall, salivaomics represents a promising approach for the early diagnosis, prevention, and management of neurodegenerative diseases through non-invasive biomarker profiling and multi-omics integration.
PMID:
42265465
Bibliographic data and abstract were imported from PubMed on 12 Jul 2026.
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