Changes in trauma symptoms of discrimination after MDMA-assisted psychotherapy for posttraumatic stress disorder.

Authors

Monnica T Williams, Sonya C Faber, Jordan Sloshower, Lianna Tullis-Robinson, Sergio R Pérez Rosal

Published in

Scientific reports. Jul 11, 2026. Epub Jul 11, 2026.

Abstract

This preliminary study explored the effects of MDMA-assisted therapy on trauma symptoms related to discrimination, as measured by the Trauma Symptoms of Discrimination Scale (TSDS). A total of five diverse participants, who experienced multiple types of discrimination (e.g., gender, racial/ethnic, social class, age, sexual orientation), were assessed before and after treatment. A paired-samples t-test indicated a significant reduction in TSDS scores following therapy, with mean scores decreasing by 38% (t(4) = 2.85, p = .046). The effect size was large (Cohen's d = 1.28), though this estimate should be interpreted cautiously given the small sample size. All participants reported marked improvements in discrimination related trauma symptoms following MDMA-assisted therapy in this sample, and across different racial/ethnic identities and discrimination histories. These findings provide preliminary evidence that MDMA-assisted therapy may effectively alleviate discrimination-related trauma in marginalized populations. We discuss the importance of culturally-informed treatment approaches for psychedelic-assisted psychotherapy. These early results warrant further investigation in larger, more diverse cohorts.

PMID:
42436172
Bibliographic data and abstract were imported from PubMed on 12 Jul 2026.

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