Spatial omics and its applications for a tumour microenvironment characterization and precision medicine approach of gastric cancer.

Authors

José Darío Portillo-Miño, John Jairo Calderon, David Bettin Gonzalez, Yeison Carlosama, Lorena Lagarde, Rafael Parra-Medina

Published in

Ecancermedicalscience. Volume 20. Pages 2140. Epub Jun 04, 2026.

Abstract

Gastric cancer (GC) is a lethal disease due to heterogeneity and complexity from the point of view of epidemiology, epidemiology and public health policy and biological behaviour. Despite recent advances in the research field on the molecular and cellular characterisation of GC, the clinical outcomes have been ominous. Perhaps the unceasing research in future years, focusing on spatial omics, has revolutionary potential for transforming the conception and understanding of GC mechanisms, thereby enabling the discovery of targeted therapies that are most effective in improving survival. Under these circumstances, this review article lays the groundwork for an update of spatial omics, offering a comprehensive vision and its implications for understanding the landscape of GC research. Moreover, it highlights the recent advances and breakthroughs in heterogeneity and immunosuppressive tumour microenvironment.

PMID:
42437070
Bibliographic data and abstract were imported from PubMed on 12 Jul 2026.

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