Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior.

Authors

Bianca Preissing, Franziska Sackel, Marija Trajkovic-Arsic, Lennard Rohr, Anna-Lena Linke, Melanie Bewerunge-Hudler, Sven-Thorsten Liffers, Jens Thomas Siveke, Stefan Herlitze, Ida Siveke

Published in

iScience. Volume 29. Issue 7. Pages 116615. Jul 17, 2026. Epub Jul 02, 2026.

Abstract

We have developed an optogenetic tool called InLOV-an insulin receptor fused to a LOV domain-that enables activation of the insulin receptor signaling pathway via light-induced phosphorylation of its intracellular domains. Light activation of InLOV promotes insulin-induced neuronal plasticity in the mouse cerebellum and enhances cerebellar-driven self-motion behavior. Thus, InLOV enables optogenetic modulation of insulin receptor phosphorylation, opening new possibilities for disease modeling and therapeutic strategies for pathological insulin signaling in humans.

PMID:
42437004
Bibliographic data and abstract were imported from PubMed on 12 Jul 2026.

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