Current Evidence for Circulating Tumor DNA in Sarcoma: Challenges and Opportunities for Clinical Application.

Authors

Kristin E Goodsell, Jason A Carter, Hannah R Abrams, Harveshp Mogal, Elizabeth T Loggers, Jeremy Sharib

Published in

Journal of surgical oncology. Jul 12, 2026. Epub Jul 12, 2026.

Abstract

Sarcomas represent a diverse group of mesenchymal tumors with high rates of recurrence after resection. While recent technical advances have enabled the detection of rare circulating tumor DNA (ctDNA) in other malignancies, the complexity and heterogeneity of sarcoma genomics have historically limited ctDNA in these cancers. This narrative review highlights the rapidly evolving evidence supporting potential clinical applications of ctDNA in common sarcoma subtypes including gastrointestinal stromal tumor, leiomyosarcoma, rhabdomyosarcoma, osteosarcoma, and Ewing sarcoma.

PMID:
42437510
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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