Early duodenal signet-ring cell carcinoma covered by gastric foveolar metaplasia.

Authors

Kazuki Horiuchi, Kei Kato

Published in

Internal medicine (Tokyo, Japan). Jul 11, 2026. Epub Jul 11, 2026.

Abstract

A 52-year-old man underwent esophagogastroduodenoscopy during a routine health checkup, which revealed a 15 mm semipedunculated lesion in the duodenal bulb. The initial biopsy revealed Brunner's gland hyperplasia with gastric foveolar metaplasia (GFM). A second biopsy performed 6 months later revealed signet-ring cell carcinoma (SRCC) beneath a thick overlying layer of GFM, and endoscopic mucosal resection was thus performed. The carcinoma was confined to the mucosa only. Both the SRCC and the overlying GFM exhibited a gastric-type phenotype, with an in situ lesion identified within the GFM. We report a diagnostically informative case of early duodenal SRCC.

PMID:
42438031
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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