Adrenal Incidentaloma Presenting with Testicular Swelling and Transient Tumor Regression on Computed Tomography.

Authors

Yosuke Sazumi, Yasuhiro Nakano, Atsushi Kato, Atsuhito Suyama, Kohei Oguni, Koichiro Yamamoto, Miho Yasuda, Kanako Ochi, Yuya Kawago, Nobuharu Fujii, Fumio Otsuka

Published in

Internal medicine (Tokyo, Japan). Jul 11, 2026. Epub Jul 11, 2026.

Abstract

Adrenal incidentalomas are typically monitored for tumor growth during follow-up visits. We report the case of a 70-year-old man with a non-functioning left adrenal mass that exhibited transient regression and was ultimately diagnosed as diffuse large B-cell lymphoma. The diagnosis was suspected based on elevated serum lactate dehydrogenase levels and left testicular enlargement, prompting an evaluation using fluorodeoxyglucose positron emission tomography/computed tomography and confirmation by radical orchiectomy. This case highlights the importance of considering malignant lymphoma when adrenal masses regress transiently and underscores the risk of adrenal insufficiency even after the completion of lymphoma treatment.

PMID:
42438020
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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