The adhesion G protein-coupled receptor F5 (ADGRF5) as an architect of immune response in cancers.

Authors

Damian Jacenik

Published in

Biochimica et biophysica acta. Reviews on cancer. Pages 189662. Jul 12, 2026. Epub Jul 12, 2026.

Abstract

The adhesion G protein-coupled receptor F5 (ADGRF5) has emerged as a critical regulator of cellular homeostasis and disease pathogenesis. Recent investigations have revealed its dual role in driving intrinsic cancer cell aggressiveness, while orchestrating the tumor microenvironment, highlighting its untapped potential in immunotherapeutic strategies. This review provides insights into the impact of ADGRF5 expression and signaling on cancer and immune cells, underlining the essential role of ADGRF5 in cancer-related immunity. Furthermore, based on recent experimental data, the translational aspects of ADGRF5 properties are elaborated, providing a future perspective within the therapeutic area of immunooncology.

PMID:
42437594
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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