Tyramine is not essential for European foulbrood pathogenesis in a virulent Melissococcus plutonius strain.

Authors

Mariko Okamoto, Keiko Nakamura, Ryuichi Uegaki, Mariko Harada, Takahiro Inoue, Rana Okawaki, Daisuke Takamatsu

Published in

The Journal of veterinary medical science. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

European foulbrood, caused by Melissococcus plutonius, is a major bacterial disease of honey bee brood. Although strains belonging to the genetically related group known as clonal complex 12 (CC12) are highly virulent, their virulence factors remain unclear. Since tyramine has been proposed as a putative virulence factor, we constructed a knockout mutant of the putative tyrosine decarboxylase gene (tdc) from a CC12 strain to assess its role in pathogenicity. The tdc knockout mutant lost the ability to produce tyramine, confirming that tdc is responsible for tyramine production. However, the mutant showed no attenuation in virulence toward honey bee brood. These results suggest that tyramine production is not essential for the pathogenicity of CC12 strains in European foulbrood.

PMID:
42438008
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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