Disseminated Varicella-Zoster Virus Infection Following a Live Attenuated Varicella Vaccine (Oka Strain) in a Patient with Rheumatoid Arthritis: A Case Report.

Authors

Fuminori Taniguchi, Koji Kamiya, Naomi Nakano, Takeo Sato, Shotaro Yamamoto, Katsuya Nagatani, Yasuo Nagafuchi, Mayumi Komine, Junichi Sugai, Tetsushi Yoshikawa, Kojiro Sato

Published in

Internal medicine (Tokyo, Japan). Jul 11, 2026. Epub Jul 11, 2026.

Abstract

A 77-year-old woman was being treated for rheumatoid arthritis with prednisolone, methotrexate, and iguratimod. The patient was administered a live-attenuated varicella vaccine (Oka strain) for herpes zoster prevention by a primary care physician. Four weeks later, a vesicular rash appeared on the body. The patient was treated with amenamevir, and the rash improved. Based on the pathological findings and viral genotyping, she was diagnosed with a vaccine-induced disseminated varicella-zoster virus infection. For herpes zoster vaccination, caution is warranted as some medical questionnaires for vaccination do not include glucocorticoid use or immunosuppressive therapy, and some primary care physicians administer live vaccines only.

PMID:
42438029
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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