Reversible fluorescence OFF/ON switching of a trifluoromethyl analog of the green fluorescent protein chromophore.

Authors

Ayami Nakatsuka, Soma Hashimoto, Moe Kato, Yuichi Kuboki, Aki Fujisaka, Masahiro Ikejiri

Published in

Organic & biomolecular chemistry. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

A reversible OFF/ON fluorescent switch was developed based on the photoisomerization of a green fluorescent protein chromophore analog. In cyclohexane, ultraviolet irradiation quenches its blue fluorescence via Z-to-E photoisomerization, while treatment with nucleophiles (e.g., piperidine) restores emission through an E-to-Z nucleophile-mediated addition/elimination process.

PMID:
42439106
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.

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