Authors
Thomas Kreuz
Published in
Biological cybernetics. Volume 120. Issue 3-4. Jul 13, 2026. Epub Jul 13, 2026.
Abstract
By introducing the twin concepts of reliability and precision along with the corresponding measures, Mainen and Sejnowski's seminal 1995 paper "Reliability of spike timing in neocortical neurons" (Mainen and Sejnowski 1995) paved the way for a new kind of quantitative spike train analysis. In subsequent years a host of new methods was introduced that measured both the synchrony among neuronal spike trains and the directional component, e.g. how activity propogates between neurons. This development culminated with a new class of measures that are both time scale independent and time resolved. These include the two spike train distances ISI- and SPIKE-Distance as well as the coincidence detector SPIKE-Synchronization and its directional companions SPIKE-Order and Spike Train Order. This contribution to the special issue will not only review all of these measures but also include two recently proposed algorithms for latency correction which build on Spike Train Order and aim to optimize the spike time alignment of sparse spike trains with well-defined global spiking events. For the sake of clarity, all these methods will be illustrated on artificially generated data but in each case exemplary applications to real neuronal data will be described as well.
PMID:
42439961
Bibliographic data and abstract were imported from PubMed on 13 Jul 2026.
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