N-Isocaproyl-L-Arginylglycine Hexamethylenediamide, First Low-Molecular-Weight Mimetic of Neurotrophin-4: Design and Neuroprotective Activity.

Authors

T A Gudasheva, N I Sokolenko, K N Kolyasnikova, T A Antipova, L F Zainullina, M S Sergeeva, V L Dorofeev

Published in

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

A dimeric dipeptide mimetic of neurotrophin-4 (NT-4), N-isocaproyl-L-arginylglycine hexamethylenediamide (GZS-411), was designed based on the β-turn structure of NT-4 loop 1. GZS-411 activated the TrkB receptor similarly to the full-size neurotrophin. Neuroprotective activity of GZS-411 was observed in vitro with HT-22 mouse hippocampal cells exposed to oxidative stress or glutamate toxicity and was exerted at concentrations from 10^-9 to 10^-5 and from 10^-8 to 10^-5 М, respectively. In SH-SY5Y human neuroblastoma cells exposed to 6-hydroxydopamine toxicity, GZS-411 was active at concentrations from 10^-7 to 10^-5 М. The neuroprotective effect of GZS-411 was not inferior to that of the full-size protein in all models.

PMID:
42443573
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.