Authors
Arnon Nagler, Jordi Esteve, Jacques-Emmanuel Galimard, Depei Wu, Erlie Jiang, Nathalie Dhedin, Anne Sirvent, Jan Vydra, Jakob Passweg, Bruno Lioure, Jaime Sanz, Jurjen Versluis, Yajing Xu, Cristina Castilla-Llorente, Rodrigo Martino Bufarull, Victoria Potter, Nour Ben Abdeljelil, Eolia Brissot, Ali Bazarbachi, Bipin Savani, Sebastian Giebel, Mohamad Mohty, Fabio Ciceri
Published in
Bone marrow transplantation. Jul 13, 2026. Epub Jul 13, 2026.
Abstract
We compared the presence of additional chromosomal abnormalities (ACAs, n = 345) with a referent group with no ACAs (n = 169) (noACAs) in patients with Ph+ ALL receiving TKI before transplantation. The groups did not differ significantly in age, gender, or interval from diagnosis to transplantation. More patients with ACAs received PB grafts (86.4% vs. 78.1%, p = 0.03), while more patients in the noACAs group received myeloablative conditioning (87% vs. 75.9%, p = 0.003). Day 30 ANC (≥109/L) was 97.9% vs. 98.2%, and day 60 platelet count (≥20 × 109/L) was 93.9% vs. 95.5%. Day 100 acute GVHD grades II-IV was 26.4% vs. 31%, and of grades III-IV was 8.6% vs. 9.7%. 4-year chronic GVHD was 40.5% vs. 39.9%, and the proportion of extensive chronic GVHD was 19.3% vs. 20.1%. 4-year NRM was 13.1% vs. 13.5%, and 4-year RI was 19.2% vs. 21.1%; 4-year LFS and OS were 67.7% vs. 65.4% and 76.3% vs. 78.5%. 4-year GRFS was 48.5% vs. 45%, respectively. In multivariable analysis, having ACAs and the number of ACAs did not significantly affect transplant outcomes. Administration of a TKI upfront, followed by transplantation, may overcome the poor prognostic influence of ACAs in Ph+ ALL.
PMID:
42443469
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.
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