Dual-Mode Sensing Platform Based on Eu/Ag-Ca MOF for Cysteine Detection: Synergistic Enhancement of Fluorescence and Catalytic Activity by Ag.

Authors

Shuang Yang, Yin-Sheng Liu, Bing Yan

Published in

Inorganic chemistry. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

Cysteine (Cys), an important sulfur-containing biomarker, is closely associated with various diseases, yet achieving selective recognition and multifunctional signal output within a single platform remains challenging. Herein, a site-selective coordination strategy is employed to construct a synergistic Eu/Ag-Ca metal-organic framework (MOF) by incorporating Eu³⁺ and Ag⁺ into a Ca-based framework. Ag⁺ enhances Eu³⁺ luminescence by modulating energy transfer, while simultaneously serving as catalytic active sites to impart oxidase-like activity and as specific recognition sites for Cys via strong thiol affinity. Based on these synergistic effects, a dual-mode fluorescence/colorimetric sensing platform is developed, enabling rapid, selective, and sensitive detection of Cys with cross-validated signals. Furthermore, integration into a hydrogel matrix combined with RGB analysis and logic gate design allows visual and quantitative evaluation of abnormal Cys levels. This work provides a rational strategy for constructing multifunctional MOF-based sensing systems.

PMID:
42443726
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.

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