Sit-to-stand strategies and anticipatory momentum transfer adjustments in individuals with Parkinson's disease using markerless motion capture: a cross-sectional study.

Authors

Phunsuk Kantha, Natcha Charususin, Sunee Bovonsunthonchai, Jim Richards, Rommanee Rojasavastera, Piyaporn Wichaidit, Prayook Jatesiktat, Wei Tech Ang, Prachaya Srivanitchapoom, Fuengfa Khobkhun

Published in

Scientific reports. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

Parkinson's disease (PD) impairs sit-to-stand performance due to bradykinesia and postural instability; however, specific movement strategies and anticipatory momentum transfer adjustments (AMTA) remain unclear. Markerless motion capture offers an accessible alternative to quantify kinematics. This study compared sit-to-stand strategies and AMTA between individuals with PD and healthy controls, and evaluated their correlation with clinical assessments. Fifteen individuals with PD and 15 healthy controls performed a self-selected sit-to-stand (STS) test and the five-times sit-to-stand test (FTSST). Movements of the head, trunk, hip, knee, and ankle were recorded using markerless motion capture across four self-selected STS phases and the FTSST momentum transfer phase. Clinical assessments included the Mini-Balance Evaluation Systems Test (Mini-BESTest), Falls Efficacy Scale-International (FES-I), and the Movement Disorders Society-Unified Parkinson's Disease Rating Scale motor examination (MDS-UPDRS Part III). The PD group required more time to complete both tasks compared to controls (all adjusted p < 0.050). During the self-selected STS, individuals with PD exhibited earlier onset of head and trunk movement during Phase I (Flexion Momentum) and lower peak angular extension velocities of the head, hip, and knee during Phase III (Extension) (all adjusted p < 0.050). No between-group differences were observed in postural sway during Phase IV (Stabilization) (all adjusted p > 0.050). During the FTSST, the PD group demonstrated longer durations for the AMTA1 and AMTA2 sub-phases (adjusted p = 0.037). No other kinematic differences remained significant after correction for multiple comparisons (all adjusted p > 0.050). Correlation analyses revealed low-to-moderate associations (|r| = 0.365 to 0.635, p < 0.050) between clinical outcomes (Mini-BESTest scores and MDS-UPDRS Part III) and kinematic parameters. Individuals with PD exhibit disease-specific sit-to-stand compensation characterized by early head and trunk initiation. During the FTSST, momentum transfer relies primarily on trunk extension rather than lower limb extension. These findings highlight altered segmental coordination strategies and anticipatory duration in PD, which are detectable using markerless motion capture.Trial registration: The study was registered with the Thai Clinical Trials Registry (TCTR20250112013; registered on 12/01/2025) prior to data collection. Ethical approval for the study was obtained from the Mahidol University Institutional Review Board, Mahidol University, Thailand (COA No. MU-MOU 2024/330.2612; approved on 26/12/2024) which was carried out fully in accordance with the ethical standard guidelines of the Declaration of Helsinki.

PMID:
42443456
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.

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