Reciprocal relationships between self-stigma, psychological distress, and suicidality among individuals with schizophrenia: a random intercept cross-lagged panel model with a one-year follow-up.

Authors

Yun-Ling Chen, Hsin-Chi Tsai, Hsiao-Wei Huang, Thao Thanh Thi Nguyen, Yen-Chun Wang, Yu-Ting Huang, Daniel Kwasi Ahorsu, Jung-Sheng Chen, Kun-Chia Chang, Marc N Potenza, Chung-Ying Lin

Published in

European archives of psychiatry and clinical neuroscience. Jul 14, 2026. Epub Jul 14, 2026.

Abstract

Self-stigma, psychological distress, and suicidality are interrelated constructs in schizophrenia, yet their temporal relationships remain unclear. This study examined reciprocal relationships among self-stigma, psychological distress, and suicidality in individuals with schizophrenia using a cross-lagged model over one year. Participants with schizophrenia were recruited from a psychiatric teaching hospital in southern Taiwan. Data were collected at five time points, each three months apart, over a one-year follow-up period. Among the 241 participants, 137 completed all five times of measures. Self-stigma was measured using the Self-Stigma Scale-Short (SSS-S), psychological distress using the Depression, Anxiety, Stress Scale-21 (DASS-21), and suicidality using the suicidality module of the Mini International Neuropsychiatric Interview (MINI). Random-intercept cross-lagged panel models were employed to examine bidirectional relationships for two datasets: entire participants (i.e., 241 with full information maximum likelihood handling missing values) and 137 participants. The models demonstrated excellent fit (comparative fit index [CFI] = 0.991 and 0.995, root mean square error of approximation [RMSEA] = 0.051 and 0.032). Significant bidirectional effects were found between self-stigma and psychological distress across multiple waves (β = 0.13-0.36). Psychological distress related to subsequent suicidality (β = 0.16-0.19), while suicidality related to subsequent distress (β = 0.15-0.16) and subsequent self-stigma (β = 0.15-0.19). Self-stigma and suicidality rates remained relatively stable over time. Self-stigma and psychological distress sometimes exhibited reciprocal relationships over time, with distress serving as a key pathway to suicidality in schizophrenia. However, such reciprocal relationships were not consistent throughout the five-wave measures. These findings support integrated interventions targeting both self-stigma and psychological distress to reduce suicide risk.

PMID:
42443538
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.

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