Authors
Elvi Gil Lievana, Benjamin Arroyo, Jesús Pérez-Ortega, Axel Lopez, Luis Rodriguez-Blanco, Xarenny Diaz, Gustavo Hernandez, Alam Coss, Emily Alway, Naama Reicher, Enrique Hernández-Lemus, Maya Kaelberer, Diego V Bohórquez, Ranier Gutierrez
Published in
eLife. Volume 14. Jul 14, 2026. Epub Jul 14, 2026.
Abstract
Elucidating the neuronal circuits that govern appetite requires precise, high-resolution monitoring of the microstructure of solid food consumption, a need unmet by existing tools, which are either costly or lack the temporal resolution to align feeding events with neuronal activity. To overcome this, we developed the Crunchometer, a low-cost, open-source acoustic system that uses computational algorithms to generate high-resolution feeding ethograms from the sounds produced during solid food consumption. Validation across energy states (hunger/satiety) confirmed its sensitivity to changes in feeding microstructure, and the system reliably detected semaglutide-induced suppression of intake and reduced preference for a high-fat diet. Leveraging its seamless integration with in vivo recordings in freely behaving mice, we paired the Crunchometer with lateral hypothalamus (LH) electrophysiology to identify 'meal-related' neurons that track entire meals rather than individual bouts. Calcium imaging further revealed that distinct subsets of LH GABAergic and glutamatergic neurons were tuned to feeding only, to licking only, or to both behaviors. Thus, LH neuronal ensembles differentially encode the consumption of solid food versus liquid sucrose. These findings demonstrate that the Crunchometer is a robust, accessible platform for dissecting the neural correlates of feeding behavior at the resolution of a single bite.
PMID:
42444443
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.
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