Authors
Carolina Gonzalez De Figueras, Pablo Catarecha, César Menor-Salván, Jorge Díaz-Rullo, Antonio Leyva, Eduardo González Pastor, Víctor de Lorenzo
Published in
Microbial biotechnology. Volume 19. Issue 7. Pages e70409.
Abstract
The construction and performance of plants capable of detoxifying the organochlorine pesticide (lindane, γ-hexachlorocyclohexane or γ-HCH) is reported. To this end, the bacterial linA gene from Sphingobium japonicum strain UT26, which encodes a dehydrochlorinase initiating γ-HCH degradation, was engineered into Arabidopsis thaliana. The resulting lines expressing linA exhibited markedly enhanced tolerance to lindane compared to wild-type controls, both in synthetic media and in contaminated soils. Furthermore, thereby engineered plants also removed more than 90% of the pollutant from the medium within 4 weeks. Chemical analyses revealed not only the formation of 1,2,4-trichlorobenzene (TCB), the expected γ-HCH degradation intermediates, but also detected 1,4-dichlorobenzene (DCB), suggesting that native plant activities could further push the degradation process beyond the canonical microbial pathway. This points to a potentially synergistic interaction between the introduced bacterial enzyme and the endogenous plant detoxification systems. By combining bacterial catabolic activity with plant resilience and root-mediated soil interactions, our data advocate a new strategy for the remediation of γ-HCH contaminated environments and demonstrate the feasibility of designing plants for enhanced degradation of persistent organic pollutants.
PMID:
42444123
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.
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