Authors
Francisco Juárez-Carrillo, Julio C Ontiveros-Rodríguez, Mónica Luna-Vázquez, Joel E López-Meza, Rosa E Del Río, José Carlos Espinoza-Hicks, Alejandra Ochoa-Zarzosa, Carlos M Cerda-García-Rojas, Hugo A García-Gutiérrez
Published in
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35. Issue 3. Pages 563-580. Epub Jan 15, 2026.
Abstract
Medicinal plants are an invaluable source of specialized metabolites with unique and complex chemical structures. This chemical diversity offers a rich resource for discovering new compounds with therapeutic potential. One notable example is Ageratina petiolaris, which produces a mixture of esters of 2α-hydroxyeperuic acid (1) in high quantity. The ent-labdane 2, a product of the alkaline hydrolysis of 1, possesses a chemical structure with promising therapeutic potential. In this work, aniline, cyclohexylamine, 4-chloroaniline, bencilamine, p-cinnamyl alcohol, phenol, 4-bromophenol, and 4-methoxyphenol were used to prepare ester and amide derivatives of 2 in a one-pot process aided with sonochemistry, yielding the respective compounds in moderate to good yields. Additionally, the antiproliferative potential of the amides and esters was tested in vitro against MCF-7, HeLa, A549, and K562 cancer cell lines. The results showed significant cytotoxic activity for almost all the evaluated derivatives, making them promising candidates for potential therapeutic agents against certain types of cancer.
PMID:
42446652
Bibliographic data and abstract were imported from PubMed on 14 Jul 2026.
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