Authors
Jesse T R Spooner, Daniel A Igel, Surena F Matin
Published in
The Journal of urology. Pages 101097JU0000000000005216. Jul 14, 2026. Epub Jul 14, 2026.
Abstract
Accurate mapping of lymph-node metastasis (LNM) in upper tract urothelial carcinoma (UTUC) guides lymph node dissection (LND) templates, and impacts staging and adjuvant therapy decisions. LNM patterns for mid and distal ureteral tumors remain under-characterized. Herein, we map LNM for mid and distal ureteral UTUC.
Retrospective single-institution study of 24 patients with clinical or pathological node-positive mid and distal UTUC defined by preoperative imaging, biopsy, and/or pathology following template lymphadenectomy. We recorded tumor laterality/location and nodal location/quantity. Descriptive statistics summarized distributions.
45 primary LNMs were documented in 24 patients: right mid (n = 3 patients, 9 LNM), right distal (n = 8, 14 LNM), left mid (n = 4, 8 LNM), and left distal (n = 9, 14 LNM). Among mid-UTUC, LNMs were distributed between retroperitoneal (53%, n = 9/17) and pelvic (47%, n = 8/17) regions. Among distal-UTUC, 61% (17/28) involved pelvic nodes with retroperitoneal LNMs comprising 39% (11/28). Among patients with retroperitoneal spread, isolated retroperitoneal LNMs without pelvic nodal involvement were observed in 33% (n = 1/3) and 83% (n = 5/6) of mid- and distal-UTUC patients.
This is the largest mapping series for mid and distal ureteral tumors to date. Retroperitoneal LNMs occurred in over half of mid- and over one-third of distal-UTUC patients, and among patients with retroperitoneal spread, the majority had retroperitoneal LNM without concurrent pelvic LNMs. These findings provide anatomic data to inform putative dissection templates for surgeons and future prospective studies.
PMID:
42447061
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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