Peripubertal Changes in Asthma.

Authors

Alexandra E Silva, Giuliana Ferrante, Patricia Silveyra, Adnan Custovic, Stefania La Grutta, Erick Forno

Published in

American journal of respiratory and critical care medicine. Jul 14, 2026. Epub Jul 14, 2026.

Abstract

Asthma is a heterogeneous disease affecting nearly 300 million people around the world. It is the most common chronic respiratory disease of childhood. There are significant sex differences in asthma incidence, severity, and morbidity around the time of puberty. The reasons for these peri-pubertal changes around the time of puberty are still not fully understood but they are likely multifactorial. In this review, we will discuss several proposed contributing mechanisms, including sex differences in anatomy and development, the effects of sex hormones on airway inflammation and reactivity, the immunomodulatory effects of sex hormones, differences in mucociliary function, and sex differences in genetic and epigenetic factors.

PMID:
42447233
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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