[Incidence of the progression and remission of cognitive decline in older adults].

Authors

Diana Aide González-Sotelo, Arelhi Yosajandhi Bermúdez-Rojas, María Guadalupe Berumen-Lechuga, Violeta Castro-Leyva, María Esther Bobadilla-Serrano, Yazmin Jocelyn Julián-Hernández, Mauricio Espinosa-Lugo, Jaime Juárez-González, Arturo Hernández-Esquivel, Jessica Camacho-Ruiz, Rosalinda Sánchez-Arenas

Published in

Revista medica del Instituto Mexicano del Seguro Social. Volume 64. Issue 4. Pages e6979. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

In communities with higher social inequality, tracking the progression and remission of cognitive dysfunction (PR-CD) and its associated factors provides an epidemiological overview of dementia risk.
To investigate the incidence and factors associated with PR-CD in older adults (OAs) at three clinics of the Mexican Social Security Institute in an industrial area of Western Mexico State.
A two-year longitudinal study of 231 OAs (≥ 60 years) assessed cognitive function using the Montreal Cognitive Assessment (MoCA). After 2 years, outcomes were categorized into three groups: healthy cognitive function (MoCA scores > 20 on all three measurements), remitting cognitive impairment (one or two measurements with MoCA scores < 20), and progressive cognitive impairment (MoCA scores < 20 on all three measurements). Additionally, sociodemographic, clinical, and functional data were collected. Cumulative incidence and relative risk factors were analyzed using regression.
The sample consisted of individuals with six or fewer years of schooling, and 70% identified as female. The incidence of P-CD was 28.1%, while that of R-CD was 32.5%. Factors associated with R-CD included low cognitive reserve and diminished physical performance. In contrast, factors linked to P-CD included age, low educational attainment, low cognitive reserve, age-related sarcopenia, education-related sarcopenia, age-related instrumental Activities of Daily Living (IADLs), and the interaction among age, cognitive reserve, IADLs, and SPBB.
In a region of social inequality in Western Mexico State, there is a high incidence of R-CD and P-CD, associated with risk factors that contribute to cognitive dysfunction among OAs.

PMID:
42447306
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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