[Early detection of Insuline Resistence in Pregnant Women].

Authors

Sergio Iván Domínguez-Santos, Cesar Arturo Serrano-Arrazola, Corina Mariela Alba-Alba

Published in

Revista medica del Instituto Mexicano del Seguro Social. Volume 64. Issue 4. Pages e6882. Jul 13, 2026. Epub Jul 13, 2026.

Abstract

Gestational diabetes due to insulin resistance (IR) is a priority health problem for the WHO given its consequences for both mother and fetus.
To determine the suitability of HOMA-IR for early detection of insulin resistance in the first trimester of pregnancy.
A quantitative, comparative, and correlational study was conducted in 30 pregnant women, selected by convenience sampling. IR was determined in the first trimester using the HOMA-IR test with cut-off points based on pre-pregnancy Body Mass Index (BMI) in the first trimester and oral glucose tolerance test (OGTT) in the second trimester. Analysis was performed using SPSS with the following statistical methods: Shapiro-Wilk normality test; Pearson's and Spearman's r correlation coefficients; Levene's test for independent samples; Student's t-test; and Mann-Whitney U test; as well as risk analysis with respect to BMI.
The average age was 27 years. No relationship was found between HOMA-IR and sociodemographic variables or pre-pregnancy BMI. During the first trimester, HOMA-IR detected IR in 56.6% of pregnant women; while in the second trimester, the OGTT detected IR in 66.3% of pregnant women. A moderate relationship was found between HOMA-IR and OGTT values at one and two hours, but not in the fasting state. The difference in mean HOMA-IR values between the groups with and without IR persisted in the OGTT tests performed in the fasting, one-hour, and two-hour states. Pre-pregnancy BMI indicating overweight and obesity did not represent a significant risk.
The HOMA-IR study proved useful for the early detection of IR, which can be used to guide lifestyle modifications in women with risk factors. Further scientific evidence is recommended.

PMID:
42447243
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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