Authors
Francesco Fioriti, Rocco Pierpaolo Germano, Noemi La Monaca, Dona M Gunawardana, Rebecca Latter, Antonietta Santaniello, Emily Flashman, Paolo Maria Triozzi, Pierdomenico Perata
Published in
Plant physiology. Jul 14, 2026. Epub Jul 14, 2026.
Abstract
Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioactive compounds to chemically prime plants for flooding events. A high-throughput chemical genetic screen of 2237 bioactive molecules was performed using an Arabidopsis thaliana luciferase-based reporter line driven by the ALCOHOL DEHYDROGENASE promoter, a hypoxia-inducible gene involved in anaerobic metabolism. The screen identified chlorquinaldol, an 8-hydroxyquinoline derivative, as a potent inducer of hypoxia responses. Chlorquinaldol inhibits the activity of PLANT CYSTEINE OXIDASES (PCOs), which are crucial oxygen-sensing enzymes in plants, resulting in the stabilization of the ETHYLENE RESPONSE FACTOR type VII and activation of hypoxia-responsive transcription under normoxic conditions. Plants pre-treated with chlorquinaldol showed enhanced tolerance to waterlogging and submergence, indicating that chemical priming of hypoxia responses improves plant tolerance to flooding. This study demonstrates that chemical inhibition of PCOs is an effective strategy for priming hypoxia responses and improving flooding tolerance in plants.
PMID:
42447496
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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