The emerging roles of alternative splicing in modulating tumor immune responses and immunotherapies.

Authors

Xinyu He, Dengyun Zhao, Yubing Zhou, Yanan Jiang, Zigang Dong, Kangdong Liu

Published in

Cell death and differentiation. Jun 25, 2026. Epub Jun 25, 2026.

Abstract

Alternative splicing is a fundamental mechanism that expands transcriptomic and proteomic diversity and contributes to multiple biological processes, including immune regulation. Increasing evidence shows that dysregulated alternative splicing influences tumor immunogenicity, the immune landscape of the tumor microenvironment, and responses to cancer immunotherapy. Alternative splicing can alter the expression and peptide repertoire of tumor antigens, modulate major histocompatibility complex-mediated antigen presentation, and generate immunomodulatory isoforms that promote immune evasion. In addition, cell type-specific splicing programs regulate the phenotypes and functions of intratumoral immune and stromal cells, including T cells, antigen-presenting cells, myeloid cells, and fibroblasts. Splicing signatures and isoform-level alterations are also associated with clinical responses to immunotherapy, particularly immune checkpoint blockade. A better understanding of splicing dysregulation in tumor immunity may improve biomarker development, patient stratification, and therapeutic targeting of aberrant RNA processing. Overall, alternative splicing is an important regulator of tumor-immune interactions and a potential target in cancer immunotherapy.

PMID:
42350624
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.