Rational dsRNA design, scalable production and nanodelivery to enhance spray-induced gene silencing.

Authors

Guoning Zhu, Chao Xu, Tao Zhang

Published in

Communications biology. Volume 9. Issue 1. Jul 14, 2026. Epub Jul 14, 2026.

Abstract

Spray-induced gene silencing (SIGS) provides a sustainable, highly targeted alternative to chemical pesticides. This review summarizes recent advances in dsRNA technology through a design-to-delivery framework. Key focuses include bioinformatics-driven multi-target dsRNA design for improved stability and efficacy, cost-effective microbial and cell-free synthesis platforms for scalable production, and nanocarriers that protect dsRNA from degradation while enhancing delivery. Integrating rational design, efficient production, and precision nanodelivery will accelerate SIGS from laboratory concept to practical, eco-friendly tool for global crop protection and sustainable agriculture.

PMID:
42448844
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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