Authors
Niels Hansen, Monika Sadlonova, Hermann Esselmann, Christopher M Celano, Carlotta Derad, Thomas Asendorf, Maike Hohberg, Mohammed Chebbok, Stephanie Heinemann, Barbara Morgado, Tobias Titsch, Katharina Packroß, Clara Maria Knopp, Matilda-Marie Becker, Irina Günther, Iryna Krasiuk, Alina Isabel Rediske, Nicholas Paul Süttmann, Paul Thomas Itting, Oliver Wirths, Ingo Kutschka, Hassina Baraki, Christine A F von Arnim, Jens Wiltfang, FINDERI investigators
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 7. Pages e71631.
Abstract
The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery.
Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized into stages-minimal (1), notable (2), and substantial (3) decline-in the FIND DElirium RIsk factors (FINDERI) study of patients undergoing cardiac surgery. BBMs were measured preoperatively (amyloid beta [Aβ]1-42, Aβ1-40, phosphorylated tau 181 [p-tau181], p-tau217, apolipoprotein E ε4 [apoE4] and apoE).
A total of 394 patients completed follow-up investigations. POCD Stage 1 was observed in 105 (26.6%), POCD Stage 2 in 52 patients (13.2%), and POCD Stage 3 in 30 patients (7.6%). The AT217term (ratio Aβ1-40/1-42 * p-tau217) was significantly associated with POCD stages in multiple logistic regression.
Early Alzheimer's BBMs are associated with POCD in patients, suggesting that our exploratory findings assessing BBMs may support risk stratification, inform decision-making, and contribute to strategies aimed at preventing POCD.
PMID:
42449187
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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