Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum.

Authors

Yu Tu, Baodan Zhang, Meiyan Bao, Minhui Ji, Ling Liu

Published in

The Journal of antibiotics. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

One new α-pyrone derivative, acremopyrone A (1) was isolated from the soil-derived fungus Acremonium persicinum 3.2858. The structure of 1 was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Compound 1 showed significant inhibitory activity against α-glucosidase. Enzyme kinetic analysis revealed a mixed-type mode of inhibition, which was further supported by molecular docking studies.

PMID:
42449146
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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