Dietary Polysaccharides Modulate Interactions between Bacteroides and the Gut Microbiota: Gene-Level Mechanisms and Perspectives on Genome-Scale Metabolic Modeling for Community Simulation.

Authors

Yueyi Zhang, Xin Song, Lianzhong Ai, Guangqiang Wang

Published in

Journal of agricultural and food chemistry. Jul 14, 2026. Epub Jul 14, 2026.

Abstract

Bacteroides is a major gut genus involved in polysaccharide uptake and degradation, yet the gene-level mechanisms by which dietary polysaccharides modulate interactions between Bacteroides and other gut microbes remain insufficiently integrated. This review summarizes dietary-polysaccharide-driven Bacteroides interactions from the perspectives of PULs, CAZymes, released oligosaccharides, fermentation products, and GEM-based community simulation. Emphasis is placed on how PUL-CAZyme repertoires shape substrate specificity, metabolite exchange, cross-feeding, competition, commensalism, and mutualism under different glycan conditions. The review further discusses the application of GEMs to simulate Bacteroides-centered communities, including reconstruction tool selection, static and dynamic modeling frameworks, and current limitations in representing polysaccharide structure and stepwise degradation. These advances provide a framework for linking dietary polysaccharide chemistry, microbial gene functions, community metabolism, and gut health-related outcomes.

PMID:
42448574
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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