Relationship between cognitive impairment and chronic kidney disease.

Authors

Laila-Yasmin Mani, Robert John Unwin

Published in

Practical neurology. Volume 26. Issue 4. Pages 313-318. Jul 14, 2026. Epub Jul 14, 2026.

Abstract

Cognitive impairment is an under-recognised but clinically significant complication of chronic kidney disease (CKD). The global prevalence of CKD is approximately 10%, and it frequently affects neurological function, and particularly executive and language domains. This article encourages neurologists and neuropsychiatrists to consider CKD as a potential contributor to cognitive decline. By recognising the characteristic cognitive profile associated with CKD, and distinguishing it from coexisting neurodegenerative pathology, clinicians can implement early interventions that improve outcomes. We outline mechanisms that link CKD to cognitive dysfunction, present diagnostic approaches and offer multidisciplinary strategies for assessment and management.

PMID:
42448384
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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