Spindle Epithelial Tumor With Thymus-Like Differentiation in an Infant.

Authors

Kei Yu Chiu, Phillip Sale, Adrian Charles, Paul O'Neill, Santosh Valvi

Published in

Pediatrics. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is an extremely rare malignant neoplasm. Here we describe an infant girl with sublingual SETTLE. Diagnosis was complicated by initial histopathology result from incisional biopsy showing features of chronic sialadenitis. Gross total resection of the lesion demonstrated a low-grade spindle epithelial cell neoplasm, which was confirmed to be SETTLE on specialist pathology review. Previous literature has not identified a case occurring at such a young age or involving a tumor located outside the thyroid gland.

PMID:
42448351
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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