Authors
Saeed Aldarwish, Anne-Sophie Becker, Imad Kamaleddine, Clemens Schafmayer
Published in
Visceral medicine. May 16, 2026. Epub May 16, 2026.
Abstract
IgG4-related retroperitoneal fibrosis (IgG4-related RPF) is a rare systemic fibro-inflammatory disorder that may present as a mass-forming lesion, mimicking malignancy. Gastrointestinal involvement is uncommon, and acute large bowel obstruction as the initial presentation is exceedingly rare.
A 59-year-old male presented with acute abdominal pain, distension, and obstructive symptoms. Colonoscopy identified a stenosing lesion at the left colic flexure, histologically confirmed as a polypoid adenoma. Contrast-enhanced computed tomography (CT) revealed a mass infiltrating the left colic flexure, peripancreatic fat, and pancreatic tail, with significant colonic dilatation. Emergency surgery was performed due to bowel obstruction. En bloc extended left hemicolectomy, distal pancreatectomy, and wedge gastrectomy with loop ileostomy were carried out. Histopathology confirmed IgG4-related RPF involving pericolic and peripancreatic fat, sparing the pancreatic parenchyma. Serum IgG4 was within normal limits. The patient had an uneventful recovery.
This case illustrates a rare presentation of IgG4-related RPF manifesting as acute bowel obstruction. Despite imaging and clinical features suggestive of malignancy, histopathological confirmation revealed benign pathology with an inflammatory fibrosing process. Awareness of such atypical manifestations is crucial to prevent unnecessary radical oncological resections.
PMID:
42454244
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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