Allergic but not autoimmune comorbidities in children with PFAPA: A nationwide matched case-control cohort study.

Authors

Yackov Berkun, Eli Magen, Eugene Merzon, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Ariel Israel

Published in

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. Volume 37. Issue 7. Pages e70423.

Abstract

Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is the most common autoinflammatory syndrome of childhood. Although immune dysregulation is central to its pathogenesis, the broader burden of allergic and autoimmune comorbidities in PFAPA remains incompletely characterized. We aimed to evaluate the prevalence of allergic and autoimmune diseases in children with PFAPA.
We conducted a nationwide matched case-control study using electronic health records from Leumit Health Services in Israel between 2000 and 2024. Children with PFAPA were identified using a dedicated ICD-9 code and matched 1:20 with controls by age, sex, socioeconomic status, ethnicity, and year of first record. Allergic and autoimmune diagnoses were identified using predefined ICD-9 codes. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, with false discovery rate correction for multiple testing.
The cohort included 1641 PFAPA patients and 32,820 matched controls with a mean follow-up of 8.6 years. PFAPA patients had increased prevalence of asthma (49.6% vs. 37.5%; OR 1.64), allergic rhinitis (15.7% vs. 9.8%; OR 1.71), atopic dermatitis (23.0% vs. 19.9%; OR 1.21), urticaria (18.8% vs. 15.0%; OR 1.32), drug allergy (1.22% vs. 0.57%; OR 2.15), and anaphylaxis (0.55% vs. 0.20%; OR 2.78). In contrast, autoimmune diseases were uncommon and showed no consistent enrichment. Similar associations were observed for diagnoses recorded before PFAPA diagnosis.
PFAPA is associated with a broad atopic comorbidity profile but not with classical autoimmune disease. These findings suggest that PFAPA may represent a distinct immune phenotype in which episodic autoinflammation coexists with atopic susceptibility.

PMID:
42452886
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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