SAM is not the SAM(e): diastereomers of an important cofactor.

Authors

Agnes Bartels, Philipp Germer, Jennifer N Andexer

Published in

Natural product reports. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

The cofactor S-adenosylmethionine (SAM, AdoMet) is generally considered to be only its canonical (S_S,S_Cα)-SAM diastereomer. In this viewpoint, we highlight that exceptions are present in some salvage pathways and many SAM-utilising enzymes tolerate alternative configurations at the two stereogenic centres of the methionine-derived moiety. This reveals stereochemical flexibility with important implications for enzyme function and natural product biosyntheses.

PMID:
42454449
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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