[Expression of S100P in Lung Adenocarcinoma and Its Clinical Significance].

Authors

Ziyi Ding, Donghui Zhang, Nanyang Li, Kai Luo, Jiahao Chen, Binghui Ding, Qian Wang

Published in

Zhongguo fei ai za zhi = Chinese journal of lung cancer. Volume 29. Issue 5. Pages 348-360. May 20, 2026.

Abstract

Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC). Due to the lack of obvious symptoms and signs in the early stages, most patients are already in the middle or late stages at diagnosis. This makes treatment difficult and prognosis poor. Therefore, the identification of effective and specific biomarkers for lung cancer remains a focal area of research. So this study aimed to investigate the expression and clinical significance of S100 calcium-binding protein P (S100P) in LUAD.
Tissue samples of LUAD (n=50), adjacent normal lung tissue (n=50), and benign inflammatory lesions (n=50) were collected from The Affiliated Cancer Hospital, Guangzhou Medical University, used as the LUAD group, normal group and benign group. Immunohistochemistry (SP method) was employed to detect the expression of S100P, C-C chemokine ligand 4 (CCL4), and cluster of differentiation 8 (CD8) proteins. Correlation analyses were carried out.
Database analysis (UALCAN, GEPIA2) identified S100P as an mRNA with high expression in LUAD. Immunohistochemistry demonstrated that the protein levels of S100P and CCL4 were significantly higher in lung tissues of the LUAD group compared to those in the normal group and benign group (all P<0.05). The area under the curve (AUC) of S100P for differentiating LUAD was 0.943. The expression of S100P showed no significant correlation with age, sex, tumor size, or degree of differentiation (all P>0.05). Correlation analysis revealed that S100P expression was moderately positively correlated with CCL4 (r=0.611, P<0.001), and positively correlated with CD8+ lymphocyte infiltration (r=0.461, P<0.001). CCL4 expression was also positively correlated with CD8+ infiltration (r=0.400, P<0.001).
Database analysis indicates that S100P is highly expressed in LUAD and associated with a poor prognosis, making it a potential biomarker for the prognosis of LUAD. Clinical tissue analysis further shows that S100P expression is correlated with CD8+ lymphocyte infiltration in LUAD, suggesting that S100P can serve as a biomarker of lymphocyte infiltration and a potential predictor of the response to immune checkpoint inhibitors.

PMID:
42452863
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.

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