Authors
Kei Kimura, Masataka Igeta, Yusuke Yatabe, Yuko Fukumoto, Kazuma Ito, Ayako Imada, Jihyung Song, Ryuichi Kuwahara, Yuki Horio, Motoi Uchino, Yusuke Kinugasa, Masataka Ikeda
Published in
Surgery today. Jul 15, 2026. Epub Jul 15, 2026.
Abstract
To investigate the sex-related differences in postoperative complications following pelvic exenteration.
This retrospective subanalysis used a multicenter registry of patients who underwent pelvic exenteration for locally advanced or recurrent rectal cancer. We included 218 patients (177 men and 41 women) in this study. The sex-related differences in postoperative complications were evaluated, and sex-by-factor interactions were assessed using logistic regression models, including sex, each perioperative factor, and the corresponding interaction term.
A significant sex-by-surgical approach interaction was observed for Clavien-Dindo Grade II or higher complications (pinteraction < 0.01). In open surgery, Grade II or higher complications occurred in 82.7% (43/52) of men compared with 38.5% (5/13) of women, whereas no clear sex difference was observed in minimally invasive surgery (69.6% [87/125] vs. 75.0% [21/28]). No significant sex-by-surgical approach interaction was detected for grade III or higher complications. Conversely, a significant sex-by-operative time interaction was observed, which was not apparent for Grade II complications.
Sex-related differences in postoperative complications after pelvic exenteration were not uniform but emerged with increased surgical invasiveness. Therefore, sex may affect the postoperative risk under conditions of increased surgical stress.
PMID:
42455157
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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