Authors
Joseph J Boscarino, Michelle Hua, K Brianalysse Nicolena Cedeño, Sean Tran, Emily N Vanderbleek, Ferdinand E Korneli, Yolanda C Leon, Selim R Benbadis, Yarema B Bezchlibnyk, Mike R Schoenberg
Published in
Applied neuropsychology. Adult. Pages 1-8. Jul 15, 2026. Epub Jul 15, 2026.
Abstract
The lateralizing value of neuropsychological data remains an important topic. However, no research has examined the utility of Wechsler Memory Scale - Fourth Edition (WMS-IV) recognition memory composites and difference scores between these to assess their accuracy in differentiating patients with right temporal lobe epilepsy (RTLE) from left temporal lobe epilepsy (LTLE).
This observational study analyzed archival data among 41 presurgical patients with TLE to examine the predictive utility of memory recognition indices and the difference score between these composites derived from the WMS-IV in differentiating seizure laterality. Independent t-tests, chi-square, logistic regression, and receiver operating characteristic (ROC) curve analyses were conducted.
23 LTLE patients (mean age = 36.48 years, SD = 10.15) and 18 RTLE patients (mean age = 42.78 years, SD = 13.22) were selected after being diagnosed based on concordant semiology, long-term video EEG monitoring, and neuroimaging. WMS-IV recognition index difference scores (RIDS) were significantly higher in RTLE than LTLE (p = .006, d = -.909). The WMS-IV RIDS was a significant predictor of seizure laterality after controlling for sex and yielded adequate accuracy in differentiating right and left TLE cases (AUC = .742).
The current findings support the utility and adequate accuracy of the WMS-IV RIDS in improving neuropsychological lateralization in patients with TLE.
PMID:
42455616
Bibliographic data and abstract were imported from PubMed on 15 Jul 2026.
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