A Bioadhesive Wireless Bioelectric Interface for Single-Dose Prevention of Acute Lung Injury via Piezoelectric Immunomodulation.

Authors

Guopeng Xu, Mengzhen Liu, Xusheng Yang, Rui Ma, Tianle Zou, Hua Han, Paul K Chu, Guomin Wang

Published in

Nano letters. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

Effective management of acute lung injury (ALI) necessitates both prolonged pulmonary retention and precise immune modulation. Here, we report a novel bioadhesive piezoelectric immunomodulator (PNS@PDA), designed to establish a persistent and wireless bioelectric interface for on-demand immunomodulation within the pulmonary microenvironment. Utilizing a mussel-inspired polydopamine (PDA) shell, PNS@PDA exhibits robust tethering to lung parenchyma, achieving a 6.3-fold higher lung accumulation than bare piezoelectric bismuth oxychloride nanosheets (PNS) 32 h postinhalation. Meanwhile, low-intensity ultrasound (1.0 W/cm²) generates on-demand bioelectric cues (>150 mV) that reprogram macrophages from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype by suppressing oxidative stress and NF-κB signaling. In a murine ALI model, a single intranasal dose of PNS@PDA provides potent preventive protection, effectively quenching cytokine storms and restoring alveolar integrity. This work introduces an innovative, on-demand, and wireless biophysical strategy for ALI intervention, offering a generalizable paradigm for the nonpharmacological treatment of acute inflammatory disorders.

PMID:
42456033
Bibliographic data and abstract were imported from PubMed on 16 Jul 2026.

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