Immune implications and therapeutic opportunities of tumor glycosylation.

Authors

Remi Hatinguais, Stan Verjans, Joana Gomes, Sandra J van Vliet

Published in

Nature cancer. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

Aberrant glycosylation is a nearly universal hallmark of cancer cells. Tumor-associated glycans can reshape cancer cell biology and act as crucial suppressors of anti-tumor immunity. By engaging immune inhibitory receptors or by modifying the function of immune checkpoints, glycans dampen natural immune responses and immunotherapy efficacy. Therefore, glycans serve both as direct targets for anticancer interventions and as adjuvants aimed at potentiating immunotherapy success. In this Review, we provide an overview of tumor glycosylation and its impact on cancer immune surveillance. Finally, we discuss recent therapeutic developments that highlight the potential of glycans as precision cancer medicines.

PMID:
42457945
Bibliographic data and abstract were imported from PubMed on 16 Jul 2026.

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