Convergence and divergence of neuropsychological and brain functional changes in patients with type 1 and type 2 diabetes.

Authors

Ke Xu, ZhengDong Wang, Fang Liu, Lian Liu, MinTian Zhou, YuFan Wang, DaZhi Yin, Fang Fang

Published in

Brain research bulletin. Pages 112050. Jul 15, 2026. Epub Jul 15, 2026.

Abstract

Although patients with type 1 or type 2 diabetes mellitus are at risk for developing the same neuropsychological disorders, their underlying pathogeneses might be heterogeneous. Here, leveraging the unique characteristics of diabetic epidemiology in China, a total of 92 participants were recruited, including 30 with type 1 and 33 with type 2 diabetes matched for age, sex, education, diabetes duration, and HbA1c, along with 29 healthy controls. Compared with controls, both type 1 and type 2 diabetes patients exhibited higher depressive symptom scores; however, no significant differences were observed between the two diabetes types. Based on functional magnetic resonance imaging and graph theory analyses, enhanced global efficiency of functional brain networks was exclusively observed in type 1 diabetes, which was negatively correlated with depression scores. Furthermore, it is only in type 1 diabetes that the increased glycemic variability negatively correlated to the functional connectivity of amygdala. These findings suggest a shared affective burden but divergent patterns of functional network organization underpinning each diabetes types and also reflect a functional reorganization potentially related to depression in type 1 diabetes.

PMID:
42456952
Bibliographic data and abstract were imported from PubMed on 16 Jul 2026.

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