Association of periodontal condition with insulin sensitivity - results of the Oulu1935 cohort study.

Authors

Ville Myllymäki, Pekka Ylöstalo, Anna Liisa Suominen, Matti Knuuttila, Ulla Rajala, Sirkka Keinänen-Kiukaanniemi, Sirpa Anttila, Tuomas Saxlin

Published in

Acta odontologica Scandinavica. Volume 85. Pages 434-444. Jul 16, 2026. Epub Jul 16, 2026.

Abstract

To investigate whether baseline periodontal condition predicts reduced insulin sensitivity (RIS) over a follow-up period of about 15 years among participants with baseline euglycemia.
A subpopulation (n = 224) of the Oulu1935 cohort was studied. Periodontal condition was defined by the presence and number of sites with periodontal pockets (probing pocket depth ≥ 4 mm) or by the participant being edentulous. Insulin sensitivity was measured using the Quantitative Insulin Sensitivity Check Index, with the lowest tertile indicating RIS. Rate ratios (RRs) with 95% confidence intervals (CI) were estimated using Poisson regression models with a robust error variance.
RIS was observed in 21.3% of the dentate participants without periodontal pockets, 32.8% of those with 1-6 sites with pockets, 33.3% of those with ≥ 7 sites with pockets, and 40.8% of the edentulous participants. Furthermore, adjusted RRs with 95% CIs (in parentheses) for the association of periodontal condition with RIS (reference: dentate participants without periodontal pockets) were 1.4 (0.8-2.6), 1.1 (0.6-2.1), and 1.4 (0.8-2.7), respectively.
Poor periodontal condition and edentulousness predicted RIS. A healthy periodontium appears to support normal insulin function, but further studies are needed.

PMID:
42460463
Bibliographic data and abstract were imported from PubMed on 16 Jul 2026.

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