Authors
Zhaobing Han, Wei Jiang, Yue Zhao, Yannan Geng, Yuanjun Qu, Qiuyue Chen, Xiwen Geng, Guimao Cao
Published in
Frontiers in pharmacology. Volume 17. Pages 1853638. Epub Jul 01, 2026.
Abstract
Although some inhalation anesthetics have been widely used and improved surgical safety, their potential to cause cognitive decline and neurotoxicity has raised widespread concern. The pathological mechanisms of cognitive dysfunction induced by anesthesia are complex, involving multiple factors such as neuroinflammation, oxidative stress, neuronal apoptosis, microglial polarization, neurotransmitter imbalance, as well as miRNA and epigenetic regulation. However, current treatment options are limited, and there is a lack of targeted and safely effective intervention measures. Natural compounds demonstrated significant potential in the prevention and treatment of cognitive dysfunction induced by anesthesia due to their multi-target regulatory properties and good safety profiles. This review systematically explores the potential role of natural compounds in alleviating cognitive dysfunction induced by inhalational anesthetics. A total of 16 natural compounds were evaluated, including flavonoids; Saponins; Phenols/Polyphenols; Terpenes, and other compounds. The main mechanisms of action identified by the research include anti-inflammatory effects, antioxidant effects, anti-apoptotic effects, regulation of microglial polarization, and epigenetic regulation. Furthermore, the current challenges and future research directions in this field were clarified.
PMID:
42460016
Bibliographic data and abstract were imported from PubMed on 16 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 3
- Comments 0