Transcutaneous spinal cord stimulation for stroke rehabilitation: a scoping review.

Authors

Mustapha Mangdow, Amna Khawaja, Derong Yang, Amir Tabatabaei, Hui Gao, Sarah Eickmeyer, Randolph Nudo, Wen Liu

Published in

Topics in stroke rehabilitation. Pages 1-17. Jul 16, 2026. Epub Jul 16, 2026.

Abstract

Transcutaneous spinal cord stimulation (tSCS) is an emerging noninvasive neuromodulation approach for rehabilitation in individuals with stroke. Studies have suggested benefits, but evidence remains fragmented and methodologically heterogeneous.
This scoping review maps and synthesizes current evidence on tSCS for stroke rehabilitation, focusing on study design, stimulation parameters, outcome measures, and reported effects.
Following PRISMA-ScR guidelines, we systematically searched five databases (PubMed, Embase, Web of Science, CINAHL, and Google Scholar) from inception to December 2025. Two independent reviewers screened titles and abstracts, with a third resolving discrepancies. We extracted data on participant characteristics, stimulation parameters, outcome measures, and findings.
Thirteen studies met inclusion criteria, comprising five randomized and eight non-randomized designs, with sample sizes ranging from 2 to 21 participants. Most studies enrolled predominantly male individuals with chronic stroke. Four studies used multi-session protocols while nine single session protocols. Stimulation parameters varied widely amplitude (5-250 mA), frequency (15-100 Hz), carrier frequency (0-10 kHz), and pulse width (0.5-2 ms). Ten studies targeted lower-extremity function, two upper extremity functions, and one autonomic function. Multi-session trials pairing tSCS with task-specific training reported improvements in selected outcomes, though small sample sizes limit generalization.
tSCS remains an exploratory adjunctive intervention in stroke rehabilitation. Future research should prioritize adequately powered controlled trials with standardized stimulation protocols, stratification by stroke severity and chronicity, and long-term follow-up to establish clinical efficacy and optimal implementation in stroke rehabilitation.

PMID:
42460690
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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