A new stilbene derivative from the lianas of Gnetum montanum Markgr.

Authors

Truong Nhat Van Do, Hai Xuan Nguyen, Phong Thanh Nguyen, Dung My Truong, Tho Huu Le, Mai Thanh Thi Nguyen

Published in

Natural product research. Pages 1-6. Jul 16, 2026. Epub Jul 16, 2026.

Abstract

Gnetum montanum Markgr., a species belonging to the family Gnetaceae, holds significant ethnobotanical value. Its lianas have traditionally been used as treatment for inflammatory and antiseptic purposes, stimulation of blood circulation, gout and rheumatism. In this study, one new stilbene derivative named montanumgam C (1) and six previously described compounds (2-7), were isolated from the ethyl acetate extract of the G. montanum lianas. The chemical structures of all isolated compounds were elucidated by extensive spectroscopic analysis, including 1D and 2D-NMR, ESI high-resolution mass spectrometry (HRESIMS), and comparison with reference data. All compounds exhibited xanthine oxidase (XO) inhibitory activity, with inhibition rates ranging from 5.4 to 90.4% at a concentration of 100 µM. Notably, compounds 1 and 3 showed potent inhibitory effect, with IC₅₀ values of 18.8 and 13.7 µM, respectively, in comparison to a positive control, allopurinol (IC₅₀ = 2.5 µM).

PMID:
42462141
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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