Authors
Yuchen Yuan, Satoshi Okada, Kazuki Miura, Minoru Suzuki, Hiroyuki Nakamura
Published in
Langmuir : the ACS journal of surfaces and colloids. Jul 16, 2026. Epub Jul 16, 2026.
Abstract
Efficient delivery of boron is a critical determinant of the therapeutic efficacy of boron neutron capture therapy (BNCT). However, conventional boron-loaded liposomal systems often suffer from low encapsulation efficiency (EE), resulting in a significant loss of costly 10B-enriched compounds and limited practical applicability. In this study, we established a remote loading strategy for the efficient encapsulation of boron compounds into liposomes. By employing a transmembrane ion gradient, boron-encapsulated liposomes (BLPs) were prepared with an encapsulation efficiency of 42.1% and a boron-to-phospholipid (B/P) ratio of 2, demonstrating the feasibility of remote loading for boron delivery. To further enhance liposome-cell interactions, BLPs were modified with cancer cell membrane interfaces derived from MDA-MB-231 cells. The resulting CM-BLPs exhibited significantly enhanced cellular association, achieving a boron accumulation of 125 ng[B]/106 cells, and showed stable retention without detectable leakage under physiological conditions. In vitro BNCT irradiation experiments revealed that CM-BLPs exhibited greater therapeutic efficacy than both unmodified BLPs and 4-borono-l-phenylalanine (BPA). These results demonstrate the feasibility of remote loading as a practical and scalable strategy for boron delivery in BNCT with cell membrane interfaces serving as a complementary approach to enhance cellular interactions.
PMID:
42463478
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.
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